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Life passes, with us all, a day at a time; so it passed with our friend Tom, till two years were gone. Though parted from all his soul held dear, and though often yearning for what lay beyond, still was he never positively and consciously miserable; for, so well is the harp of human feeling strung, that nothing but a crash that breaks every string can wholly mar its harmony; and, on looking back to seasons which in review appear to us as those of deprivation and trial, we can remember that each hour, as it glided, brought its diversions and alleviations, so that, though not happy wholly, we were not, either, wholly miserable. Tom read, in his only literary cabinet, of one who had "learned in whatsoever state he was, therewith to be content." It seemed to him good and reasonable doctrine, and accorded well with the settled and thoughtful habit which he had acquired from the reading of that same book. His letter homeward, as we related in the last chapter, was in due time answered by Master George, in a good, round, school-boy hand, that Tom said might be read "most acrost the room." It contained various refreshing items of home intelligence, with which our reader is fully acquainted: stated how Aunt Chloe had been hired out to a confectioner in Louisville, where her skill in the pastry line was gaining wonderful sums of money, all of which, Tom was informed, was to.
Orally inhaled medications, such as those used to treat asthma, may cause a contact laryngitis, a fungal laryngitis, or both. When.
In conclusion, acamprosate has no rewarding properties as shown in place preference.
Interesting for us. Region iii corresponds to the case when decaying propagation never occurs, and there is no first-order correction to the VW related to this phenomenon, i.e., the zero-order approximation remains true. The same analytical procedure may be used to estimate d which has appeared to be much less than d + . Equations 10, 13, and 14 give the first-order approximation of the VW as a function on medium properties. According to Eq. 10, VW L + 6L ; IO, where dL d + --d + . In contrast to the zero-order approximation which depends primarily on gNa, we see that TA and XT in Eqs. 13 and 14 strongly depend on gK, the first-order approximation exhibits dependencies on both parameters in question. The dependence of VW1 d + on not directly evident from Eqs. 13 and 14. However, it can be seen from a qualitative argument presented in Appendix 3. This approach indicated that this dependence should be generic for any model.
All real estate advertising in this newspaper is subject to the Fair Housing Act, which makes it illegal to advertise "any preference, limitation or discrimination based on race, color, religion, sex, handicap, familial status or national origin, or an intention to make any such preference, limitation or discrimination." Familial status includes children under the age of 18 living with parents or legal custodians, pregnant women and people securing custody of children under 18.This newspaper will not knowingly accept any advertising for real estate that is in violation of the law. Our readers are hereby informed that all dwellings advertised in this newspaper are available on an equal opportunity basis. To complain of discrimination, call HUD toll-free at 1-800-669-9777. The toll-free number for the hearing impaired is 1-800-927-9275.
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Colony numbers in this experiment. content of the above cultures and PHA-LCM see accurately assay was Fig. for increased 4, panel described respectively that more and acebutolol.
INDEX OF DRUGS A Abacavir Sulfate . Abacavir Sulfate And Lamivudine Abacavir Sulfate And Lamivudine And Zidovudine . Abarelix 84 Abatacept 71 Abelcet 83 Abilify 85 Abilify, Discmelt 28 Acamprosate Calcium .44 Acarbose 50 Accolate .69 Accuneb 68 Accupril, Accuretic g ; .18 Accutane g ; .38 Acebutolol Hydrochloride 20 Acellular Pertussis And Diphtheria Toxoid And Haemophilus B Polysaccharide Conj Vacc And Tetanus Toxoid 107 Acellular Pertussis And Diphtheria Toxoid And Hepatitis B Virus Vaccine Recombinant And Poliovirus Vaccine Inactivated And Tetanus Toxoid 108 Acellular Pertussis And Diphtheria Toxoid And Tetanus Toxoid 107 Aceon .18 Acetadote 82 Acetaminophen And Butalbital And Caffeine And Codeine Phosphate 32 Acetaminophen And Caffeine And Dihydrocodeine Bitartrate .32, 33 Acetaminophen And Codeine Phosphate 33 Acetaminophen And Hydrocodone Bitartrate 32, 33 Acetaminophen And Oxycodone Hydrochloride 32, 33, 34 Acetaminophen And Pentazocine Hydrochloride .31 Acetaminophen And Propoxyphene Hydrochloride .33 Acetaminophen And Propoxyphene Napsylate 32 Acetaminophen And Tramadol HCl 31 Acetate And Alanine And Arginine And Aspartic Acid And Chloride Ion 104 Acetate And Alanine And Arginine And Calcium And Chloride Ion 104 Acetate And Alanine And Arginine And Chloride Ion And Cysteine 104 Acetate And Alanine And Arginine And Chloride Ion And Dextrose Anhydrous ; .91, 104 Acetate And Alanine And Arginine And Chloride Ion And Glycine 104 Acetate And Alanine And Arginine And Glycine And Histidine 91 Acetate And Calcium + 2 ; And Chloride Ion And Lactate Anion And Magnesium + 2 ; 91 Acetate And Calcium + 2 ; And Chloride Ion And Magnesium + 2 ; And Potassium + 1 ; 92 Acetate And Chloride Ion And Dextrose Anhydrous ; And Gluconate Anion And Magnesium + 2 ; 92 Acetate And Chloride Ion And Dextrose Anhydrous ; And Magnesium + 2 ; And Phosphate 92 Acetate And Chloride Ion And Dextrose Anhydrous ; And Magnesium + 2 ; And Potassium + 1 ; 92 Acetate And Chloride Ion And Dextrose Anhydrous ; And Phosphate And Potassium + 1 ; 91 Acetate And Chloride Ion And Gluconate Anion And Magnesium + 2 ; And Phosphate 92 Acetate And Chloride Ion And Gluconate Anion And Magnesium + 2 ; And Potassium + 1 ; .90, 91, 92 Acetate And Chloride Ion And Magnesium + 2 ; And Potassium + 1 ; And Sodium + 1 ; 91 Acetate And Cysteine And Histidine And Isoleucine And Leucine 104 Acetazolamide 21 Acetazolamide Sodium .90 Acetic Acid 66 Acetic Acid And Aluminum Acetate 66 Acetic Acid And Hydrocortisone 66 Acetic Acid Hydrocortisone Otic Soln g ; .66 Acetylcysteine 69, 82 Acetylcysteine g ; .69 Achromycin g ; .13 Aciphex 55 Acitretin 39 Aclovate g ; .39.
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The reduced folate carrier RFC1 ; , first cloned in 1994, mediates transport of reduced folates critical to one carbon-requiring biosynthetic reactions in mammalian cells and is a member of the Major Facilitator Superfamily of transporters 1-3 ; . RFC1 also delivers MTX and new generation antifolates into a variety of tumors, particular those of hematopoietic origin 4 ; . RFC1 exchanges folates with a broad spectrum of inorganic and organic anions and high extracellular concentrations of a variety of organic phosphates competitively inhibit RFC1-mediated folate influx 5-7 ; . This interaction between RFC1 and acetazolamide.
Lanham, md: jason aronson rowman and littlefield, 200 kranzler hr, van kirk efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.
Figure 3. Adrenoceptor-induced 1D ROS production through NADPH oxidase activity in fully differentiated 1C11NE cells. A ; Inset: extracellular release of ROS was monitored as described in Fig. 1. 1D receptor-mediated ROS production was measured over 60 min in 1C11NE cells at day 8 d8 ; or day 12 d12 ; of their differentiation program upon stimulation with 100 nM NE. Maximal ROS release was completed within 30 min stimulation with 1C11NE d12 cells only. A ; Increase of ROS release above basal level as a function of NE concentration in 1C11NE d12 cells. B ; The capacity of 1D adrenoceptor antagonists a, indoramin; b, 5-methylurapidil; c, WB-4101; d, terazosin; e, alfuzosin; f, doxazosin; g, prazosin; h, albanoquil ; to inhibit the NE-induced ROS response was calibrated using 1C11NE d12 cells. To evaluate a correlation ratio, pKB values ordinate ; measured with each drug were plotted as a function of pKI values abscissa ; . 12 different concentrations of each drug were used for each experiment, which was repeated five times. C ; An involvement of NADPH oxidase in NE-induced ROS production was monitored through activation of p47PHOX, p67PHOX and NE Rac1 NADPH oxidase subunits at the plasma membrane of 1C11 d12 cells following the same procedure as in Fig. 2. D ; The engagement of NADPH oxidase in 1D adrenoceptor-dependent signaling pathways was confirmed by using DPI. 1C11NE d12 cells were preincubated with 100 M DPI and exposed to 100 nM NE in the presence of DPI for 60 min. NE-induced ROS release was totally cancelled in DPI-treated 1C11NE d12 cells. ROS production was recorded with 1C11NE d8 and 1C115-HT d12 cells stimulated with 1 M PMA in the presence or absence of 100 M DPI. DPI inhibition of PMA-mediated ROS release was comparable between 1C11NE d8 and 1C11NE d12 cells. All data shown are representative of a set of 3 independent experiments and acidophilus.
COYLE: Robert Coyle born c1800 in Ireland, m. in Ireland, Anne Scott born c1811 in Ireland: may have come from County Derry in Ireland to NB in 1847: they settled in Canning Parish, Queens County: Children born in Ireland: 1 ; John Coyle born c1831, m. Mary - : 2 ; Mary Jane Coyle born c1834, married 16 Nov 1854 in Johnston Parish in Queens County, John Otty Indledew Deal: 3 ; William Coyle born c1837, married Martha - : 4 ; Robert Coyle born c1841: 5 ; Beresford Coyle born c1843, m. 7 Nov 1872 Johnston Parish, Margaret E.J. Emily MacFarlane : 6 ; Rachel Coyle b. c1843: 7 ; Suzannah Coyle born c1846, married 28 Jul 1864 at Washademoak Lake, Queens County, NB, James Alexander Babington. Source: MC80 2354 Saint John Branch, NBGS: Arrivals 99: our first families in New Brunswick, pages 64-65.
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Most of us have seen cases of satisfactory restoration where a finger or a toe had been cut off by accident, but few of us have known of a hand being restored. The Berlin Wochemch rift reports a case where a boy's right hand had been amputated by a feed chopper, the separation, however, was not complete, as a strip of the soft tissues, three centimeters wide, remained. In this there was an artery and the ulnar nerve, and four tendons intact. Much care was exercised in preventing infection, and in preserving asepsis. The structures were very carefully and correctly adjusted. T h e periostium, the joint ligaments, 22 tendons and the median nerve were all sutured.' The remarkable feature of this satisfactory restoration was that six hours had elapsed between the time of the injury and the time restoration was undertaken. A substance it is claimed has been found in India with which cows milk can be diluted so that the nutritious value will not be impaired and that there is no coagulation. The substance is prepared from the seeds of a tree that grows throughout Asia, which is called by the Malays Kanari. The seeds contain a large percentage of oil and albuminous matter. Ether is unsafe in marked anaemic conditions, especially when the hemoglobin is not above 50 per cent. As an internal remedy for stye, homeopathists use attenuations of pulsatilla and staphisagria. It is claimed that two or three drops of black helebore given every three or four hours for dropsy following scarletina, will be found of much value. Believe in the better side of men. It is optimism that really saves people.-Ian Maclaren and acitretin.
Acamprosate will not reduce or eliminate alcohol withdrawal symptoms.
Trypanosome membranes were incubated with buffers conM taining 0.48, 1, 2, and 3 m Zwittergent 3-14 at 4 "C for 10 min and were then ultracentrifuged 100, 000 x g for 30 min ; . The the total mixture T ; , supernatant S ; , and pellet P ; fractions were assayed forGlcNAc-PI de-N-acetylase activity using GlcMiscellaneous Analytical Methods NAc-L3H1PI as the substrate Fig. 1 ; . The total mixture showed Protein Assay-Protein samples were precipitated using the method de-N-acetylase activity Le., the production of GlcNH, -PI ; at all of Wessel and Flugge 1984 ; . protein pellets were resuspended in 50 The pl of 0.1% Triton X-100, the protein content was determined using cencentrations of the detergent concentrations tested Fig. 1, and BCA protein assay reagents Pierce Chemical Co. ; . The protein concen- lanes 3, 6 , a n However, most of the activity retration was quantitated by means of a bovine serum albumin calibra- mained with the pellet at detergent concentrations of 0.48 and tion curve. 1 mM Fig. 1, lanes 5 a n detergent concentration of 3 SDS-Polyacrylamide Gel gel m the total mixture showed some de-N-acetylase activity but, M electrophoresis was performed using 10% gels using the discontinuous buffer system of Laemmli 1970 ; . Gels werestained with silver t o detect following centrifugation, neither the pellet nor the supernatant fraction showed significant activity Fig. 1, lanes 12-14 ; . In the protein bands. Inositol Analysis-The myo-inositol contents of the synthetic sub- contrast, approximately 50% of the total de-N-acetylase activstrates and substrate product analogues were measured byGC-MS. ity could be recoveredin a stable form in the supernatant at a Sample aliquots were mixedwith 50 pmol of [1, 2, 3, 4, concentration of 2 m~ Fig. 1, lanes 9-11 1. These and then hydrolyzed with 50 pl of HC1 for 16 h at 110 "C. After conditions were used routinely to solubilize the de-N-acetylase drying the products were trimethylsilylated and analyzed by GC-MS, as described previously Ferguson, 19921, with selective ion monitoring at activity prior to its purification. Various protease inhibitors m z 305, 307, and 321.The mlz 318: 321ratio was used for calcu- were included in the solubilization buffer; one of them, N-eth318, ylmaleimide, was shown to significantly increase the yield of lating the non-deuteriated myo-inositol content. GlcNH, -PI data not shown ; . RESULTS The solubilized GlcNAc-PI de-N-acetylase preparation lost Optimization of Conditions for Solubilization of the Glc- activity upon freeze-thawing and upon prolonged storage at NAc-PI Deacetylase-No de-N-acetylase activity could be de4 "C. The inclusion of glycerol 10-50%, v v ; substantially intected upon the addition the G~cNAc-[~H]PI to trypanosome of creased the stability of the preparation, and 10%glycerol was membranes in the absence of detergent. Presumably only an included in all the buffers used for chromatography. The eninsignificant proportionof the added substrate could insert into zyme was shown to have a broad pH optimum around pH 7.4, the membranes that contained the enzyme. Several detergents with 90% of the maximum activity being expressed in the range were investigated for their ability to allow access of the sub- p H 6.4 to 8.0. The enzyme activity was unaffected by 0-1 M strate to the enzyme and to maintain de-N-acetylase activity. NaC1. Trypanosome membranes were incubated in a buffer containof GlcNAc-PI Deacetylase-The GlcPartialPurification ing the detergent at the upper limit of its critical micellar the NAc-PI de-N-acetylase was purified from supernatant fracconcentration Neugebauer, 1992 ; , andthe lysate was assayed tion obtained from trypanosome membranes solubilized in 2 for de-N-acetylase activity using G~cNAc-[~H]PI as the subm Zwittergent 3-14. Synthetic G~CN[~H]AC-PI was used to M and actimmune.
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Effect size estimates for percent days abstinent are reported as Cohen d values. Three-way interactions are not shown but all were not significant. CBI indicates combined behavioral intervention; CI, confidence interval. * Comparison group for naltrexone is placebo; for acamprosate, placebo; and for CBI, no CBI. Comparison group is placebo acamprosate placebo naltrexone. Comparison group is placebo acamprosate no CBI. Comparison group is placebo naltrexone no CBI. 2010 JAMA, May 3, 2006--Vol 295, No. 17 Reprinted.
Except DNA index P , 015 ; by logrank analysis. Finally, after adjustment for treatment was made for patients with pre-B ALL, EFS remained significantly worse for those with a t 1; 19 ; compared to all other pre-B cases with a demonstrated clonal abnormality and to all other pre-B patients, regardless of cytogenetic findings, P .001 for both comparisons. These data show the independent prognostic importanceoft l; l9 ; . If cases with the t 1; 19 ; are excluded from patients in both immunophenotypic groups with clonal abnormalities detected, the prognoses of children with pre-B ALL n 101 ; are significantly better than those of children with early pre-B ALL n 375, P .02 ; . Within the group of children with pre-B ALL, those with a t 1 ; were significantly more likely to be black 12 of 29 256, P .001 ; and to have higher leukocyte counts median, 25 x 109 L v 14 109 L, P , 026 by two-sided Wilcoxon test and adalimumab.
TORRES JUAN CARLOS HURTADO; TORRES JUAN MANUEL HURTADO Improved closure 11 December 2002 [SPAIN-11 December 2001 Spain-21 March 2002] TREVOR LOFFEL A cellular honeycomb type reinforcing structure, and a method and apparatus for forming the structure 12 December 2002 [IRELAND-12 December 2001] UNIVERSITY COLLEGE CORK A data processing system 4 December 2002 UNIVERSITY COLLEGE CORK Production of waveguides 6 December 2002 [IRELAND-6 December 2001] WOODS GERARD; KELLY IAN; DALTON RICHARD. Breath monitoring device for use in conjunction with MRI scans. 4 December 2002 and acamprosate.
Campral: Favorable Ramp in Alcohol Dependence Earlier this year in January, Forest launched Campral acamprosate calcium ; DelayedRelease Tablets for the maintenance of abstinence from alcohol in patients with alcohol dependence that are abstinent at treatment initiation. Developed by Merck KGaA, Campral is the first new medication in nine years to be approved in the U.S. for the treatment of alcohol dependence, a chronic disease that accounts for approximately 100, 000 deaths per year. Forest's marketing efforts are focused on alcohol treatment centers, addiction specialists, and a target group of physicians involved in the management of alcoholism. No sales force additions were made for the product. Forest management estimates a target market of 14 million Americans for Campral. While this may be a large market opportunity conceptually, there has yet to be a significant commercial market for alcohol dependence. Treatment of alcohol dependence with drug therapy can be challenging due to the difficulty of maintaining compliance. Patients must be monitored regularly, sometimes daily, to ensure continuation of therapy. Campral's somewhat narrow target market only patients who are currently abstinent ; and slightly burdensome dosing total a 6 pills a day ; could pressure its overall market potential. Sales of Campral were million in FQ2, and prescriptions are showing steady growth. We forecast sales of million for F2006, expanding to million by 2008. Campral was licensed to Forest in 2001. While the exact mechanism of action of Campral is not known, the drug helps reduce cravings for alcohol, and is indicated to help patients with alcoholism stay alcohol-free after they have stopped drinking. Treatment with Campral is intended to be part of a program that includes counseling and support, and the product is not effective for patients who are still drinking at the start of treatment. An oral tablet, Campral is dosed at two pills, three times a day. Under terms of the licensing agreement, Forest is responsible for sales and marketing activities of the product in the U.S.; Merck KGaA will manufacture and supply the product and adefovir.
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Blaf ml bla number proprietary name proper name applicant rc approval date bl125141 myozyme alglucosidase alfa genzyme p, o 28-apr-2006 bl125156 lucentis ranibizumab genentech p 30-jun-2006 bl125151 elaprase idursulfase shire human genetic therapies p, o 24-jul-2006 bl125147 vectibix panitumumab amgen p 27-sep-2006 drugs and biologic approvals for calendar year 2005 ml nda number drug name generic name applicant sponsor ct rc approval date 1208 n021660 abraxane paclitaxel protein-bound particles american bioscience 5 s 07-jan-05 n021726 niravam alprazolam schwarz pharma 5 s 19-jan-05 z n021841 lamivudine; zidovudine; nevirapine lamivudine; zidovudine; nevirapine pharmacare 4 p 24-jan-05 * n021642 nascobal cyanocobalamin nastech pharma 3 s 31-jan-05 n021759 eloxatin oxaliplatin sanofi-synthelabo 5 s 31-jan-05 n021758 vanos fluocinonide medicis pharma 3 s 11-feb-05 n020645 ammonul sodium benzoate; sodium phenylacetate ucyclyd pharma 5 p, o 17-feb-05 n021269 cardura xl doxazosin mesylate 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wyeth cons 3 s 24-feb-04 n050791 myfortic mycophenolic acid novartis pharms 2 s 27-feb-04 n021571 iquix levofloxacin santen 3 s 01-mar-04 1192 n021688 sensipar cinacalcet hydrochloride amgen 1 p, o 08-mar-04 n021621 zyrtec cetirizine hydrochloride pfizer 3 s 16-mar-04 n021211 follistim aq follitropin beta organon 3 s 23-mar-04 n021765 gonal-f follitropin alfa serono inc 3 s 25-mar-04 n021253 zyprexa im olanzapine eli lilly 3 s 29-mar-04 1189 n021144 ketek telithromycin aventis pharms 1 s 01-apr-04 n020784 nasacort hfa triamcinolone acetonide aventis pharms 3 s 07-apr-04 n021256 chirhostim human secretin chirhoclin 1 p 09-apr-04 n021629 apidra insulin glulisine aventis pharms 1 s 16-apr-04 1200 n021264 apokyn apomorphine hydrochloride bertek 1 p, o 20-apr-04 n021574 fortamet metformin hydrochloride andrx 5 s 27-apr-04 n021640 vitrase ovine hyaluronidase ista pharms 1 p 05-may-04 n021504 lidosite topical system lidocaine hydrochloride; epinephrine vyteris 3 s 06-may-04 n021617 zalkote valproate sodium andrx 3 s 06-may-04 * n021443 enjuvia synthetic conjugated estrogens, b duramed 3 s 10-may-04 z n021551 halflytely and bisacodyl bowel prep kit peg-3350; sodium chloride; sodium bicarbonate; potassium chloride; bisacodyl braintree 3 s 10-may-04 n021433 flovent hfa fluticasone propionate glaxosmithkline 3 s 14-may-04 1190 n021618 tindamax tinidazole presutti labs 1 s 17-may-04 n021671 depodur morphine sulfate skye pharma 3 s 18-may-04 1201 n050794 vidaza azacitidine pharmion 1 p, o 19-may-04 1191 n021361 xifaxan rifaximin salix pharms 1 s 25-may-04 n021494 axid nizatidine reliant pharma 3 s 25-may-04 n021684 gonal-f rff pen follitropin alfa serono inc 3 s 25-may-04 n021566 prevacid iv lansoprazole tap pharm 3 s 27-may-04 1188 n021595 sanctura trospium chloride indevus 1 s 28-may-04 n021530 mobic meloxicam boehringer ingelheim 3 s 01-jun-04 n021516 istalol timolol maleate senju 3 s 04-jun-04 n021667 nutresore l-glutamine nutritional restart 1 s, o 10-jun-04 1206 n021636 zegerid omeprazole santarus 3 s 15-jun-04 z n021369 codeprex codeine polistirex; chlorpheniramine polistirex celltech pharms 3 s 21-jun-04 z n021585 mucinex d guaifenesin; pseudoephedrine hydrochloride adams 3 s 22-jun-04 n021512 loratadine loratadine perrigo 3 s 24-jun-04 n050789 tobramycin tobramycin american pharm 5 s 13-jul-04 n021612 luxacor fenofibrate cipher 3 s 15-jul-04 * n021497 alinia nitazoxanide romark 3 p 21-jul-04 1191 z n021687 vytorin ezetimibe; simvastatin msp singapore 4 s 23-jul-04 n021415 metvix methyl aminolevulinate photocure asa 3 s 27-jul-04 1199 n021431 campral acamprosate calcium lipha 1 p 29-jul-04 n050792 cefotaxime and dextrose duplex container cefotaxime sodium b braun 5 s 29-jul-04 1203 z n021652 epzicom abacavir sulfate; lamivudine glaxosmithkline 3 s 02-aug-04 1203 z n021752 truvada emtricitabine; tenofovir disoproxil fumarate gilead sciences 4 p 02-aug-04 1193 n021427 cymbalta duloxetine hydrochloride eli lilly 1 s 03-aug-04 n021768 fludeoxyglucose f18 fludeoxyglucose f18 weill medical college 3 s 05-aug-04 n021749 pentetate calcium trisodium pentetate calcium trisodium pharma hameln gmbh 1 p, o 11-aug-04 n021751 pentetate zinc trisodium pentetate zinc trisodium pharma hameln gmbh 1 p, o 11-aug-04 n021633 femtrace estradiol acetate warner chilcott 3 s 20-aug-04 n021648 digoxin digoxin roxane 7 s 26-aug-04 n021678 tequin gatifloxacin bristol-myers squibb 3 s 27-aug-04 n021698 zantac ranitidine hydrochloride pfizer consumer healthcare 3 s 31-aug-04 n021300 clarinex desloratadine schering 3 s 01-sep-04 n021563 clarinex desloratadine schering 3 p 01-sep-04 n021712 fluxid famotidine schwarz pharma 3 s 24-sep-04 1204 n021044 palladone hydromorphone hydrochloride purdue pharma 3 s 24-sep-04 n021727 amlexanox amlexanox access pharms 3 s 29-sep-04 n021735 terconazole terconazole altana 5 s 01-oct-04 n021322 luveris lutropin alfa serono inc 3 s, o 08-oct-04 n021732 vantas histrelin acetate valera 3 s 12-oct-04 n021683 manoplex insoluble prussian blue degussa 5 p 14-oct-04 * n021719 aricept donepezil hydrochloride eisai medical 3 s 18-oct-04 n021720 aricept donepezil hydrochloride eisai medical 3 s 18-oct-04 z n021704 allegra-d 24 hour fexofenadine hydrochloride; pseudoephedrine hydrochloride aventis pharms 3 s 19-oct-04 n021721 levaquin levoflaxin ortho mcneil 3 s 21-oct-04 n050801 evoclin clindamycin phosphate connetics 3 s 22-oct-04 * 1228 n021468 fosrenol lanthanum carbonate hydrate shire pharm 1 s 26-oct-04 z n021486 lidocaine hydrochloride; epinephrine lidocaine hydrochloride; epinephrine empi 4 s 26-oct-04 n021665 amphadase hyaluronidase amphastar pharm 1 p 26-oct-04 n021736 xamlom amlodipine ranbaxy res 3 s 28-oct-04 * n021457 albuterol sulfate albuterol sulfate ivax res 3 s 29-oct-04 n021663 menopur menotropins ferring 3 s 29-oct-04 n021656 tricor fenofibrate abbott 3 s 05-nov-04 n021654 omacor omega-3-acid ethyl esters ross prods 1 s 10-nov-04 n021527 atrovent hfa ipratropium bromide boehringer ingelheim 3 s 17-nov-04 1205 n021743 tarceva erlotinib hydrochloride osi pharms 1 p 18-nov-04 1204 n021518 vesicare solifenacin succinate yamanouchi 1 s 19-nov-04 n021357 multihance gadobenate dimeglumine bracco 1 s 23-nov-04 n021358 multihance multipack gadobenate dimeglumine bracco 3 s 23-nov-04 z n021378 combunox ibuprofen; oxycodone hydrochloride forest labs 4 s 26-nov-04 n021695 antara fenofibrate reliant pharms 3 s 30-nov-04 n050793 clindesse clindamycin phosphate kv pharm 5 s 30-nov-04 n021786 kelacal pentetate calcium trisodium cis 5 p 01-dec-04 * n021787 kelazin pentetate zinc trisodium cis 5 p 01-dec-04 * n021713 abilify aripiprazole otsuka america 3 s 10-dec-04 n021731 eligard leuprolide acetate atrix 3 s 14-dec-04 z n050804 zylet loteprednol etabonate; tobramycin bausch and lomb 4 s 14-dec-04 1203 n021476 lunesta eszopicline sepracor 1 s 15-dec-04 n021670 vision blue trypan blue dorc international bv 1 p 16-dec-04 n021583 depo-subq provera 104 medroxyprogesterone acetate pfizer 3 s 17-dec-04 1212 n021756 macugen pegaptanib sodium eyetech pharms 1 p 17-dec-04 n021785 invirase saquinavir mesylate roche 3 p 17-dec-04 n021609 enjuvia synthetic conjugated estrogens, b duramed pharms 3 s 20-dec-04 n021706 omeprazole omeprazole santarus 3 s 21-dec-04 1204 n021513 enablex darifenacin hydrobromide novartis 1 s 22-dec-04 n021545 olopatadine hydrochloride olopatadine hydrochloride alcon 3 s 22-dec-04 n021615 reminyl galantamine hydrochloride johnson and johnson 3 s 22-dec-04 n021060 prialt ziconotide elan pharms 1 p 28-dec-04 n021673 clolar clofarabine genzyme 1 p, o 28-dec-04 n021779 ventavis iloprost cotherix 1 p, o 29-dec-04 n021446 lyrica pregabalin pfizer 1 p 30-dec-04 blaf ml bla number proprietary name proper name applicant rc approval date bl125084 erbitux cetuximab imclone systems p 12-feb-04 bl125085 avastin bevacizumab genentech p 26-feb-04 z bl125083 pegasys copegus combination pack peginterferon alfa-2a co-packaged with ribavirin hoffmann-la roche s 04-jun-04 bl103928 neutrospec technetium 99m tc fanolesomab palatin technologies s 02-jul-04 1202 1204 bl125104 tysabri natalizumab biogen idec inc p 23-nov-04 1207 bl125103 kepivance palifermin amgen, inc p 15-dec-04 nda approvals for calendar year 2003 ml nda number drug name generic name applicant sponsor ct rc approval date 1157 21434 xanax xr alprazolam pharmacia and upjohn fr 3 s 17-jan-03 21305 sodium iodide i-131 sodium iodide i-131 draximage 3, 5 s 24-jan-03 20414 pyridostigmine bromide pyridostigmine bromide us army 3 p 05-feb-03 21392 cardizem la diltiazem hydrochloride biovail 3 s 06-feb-03 21488 eligard leuprolide acetate atrix 3 s 13-feb-03 1156 21351 oxytrol oxybutynin watson labs utah ; 3 s 26-feb-03 21159 loprox ciclopirox medicis 3 s 28-feb-03 21438 innopran xl propranolol hydrochloride reliant pharms 5 s 12-mar-03 1159 21481 fuzeon enfuvirtide roche 1 p 13-mar-03 21367 femring estradiol acetate galen ltd 2 s 20-mar-03 1160 21106 somavert pegvisomant pharmacia and upjohn 1 pv 25-mar-03 1162 21549 emend aprepitant merck 1 p 26-mar-03 1179 21493 zymar gatifloxacin allergan 3 s 28-mar-03 21444 risperdal risperidone johnson & johnson 3 s 02-apr-03 1192 21158 factive gemifloxacin mesylate lg life 1 s 04-apr-03 21271 iprivask desirudin aventis pharms 2 s 04-apr-03 21475 methylin methylphenidate hydrochloride mallinckrodt 3 s 15-apr-03 1179 21598 vigamox moxifloxacin hydrochloride alcon 3 s 15-apr-03 1106 21588 gleevec imatinib mesylate novartis 3 p 18-apr-03 21503 viracept nelfinavir mesylate agouron 3 s 30-apr-03 1138 21399 iressa gefitinib astrazeneca 1 p 05-may-03 1161 21602 velcade bortezomib millennium pharms 1 p 13-may-03 1207 21-455 boniva ibandronate sodium roche 1 s 16-may-03 z 21-496 duocaine bupivacaine hydrochloride; lidocaine hydrochloride amphastar pharms 4 s 23-may-03 20-800 twinject epinephrine hollister-stier labs 3 s 30-may-03 21-528 acular ls ketorolac tromethamine allergan 3 s 30-may-03 z 21-396 prempro premphase conjugated estrogens; medroxyprogesterone acetate wyeth pharms 3 s 04-jun-03 z 21-532 benicar hct olmesartan medoxomil; hydrochlorothiazide sankyo pharma 4 s 05-jun-03 21-137 levolet levothyroxine sodium vintage pharms 5 s 06-jun-03 1182 z 21-485 stalevo carbidopa; levodopa; entacapone orion 4 s 11-jun-03 1173 21-287 uroxatral alfuzosin hydrochloride sanofi synthelabo 1 s 12-jun-03 21-559 infuvite adult multiple vitamins sabex 5 s 16-jun-03 21-543 striant testosterone columbia labs 3 s 19-jun-03 21-229 prilosec omeprazole magnesium astrazeneca lp 2, 3 s 20-jun-03 1169 21-567 reyataz atazanavir sulfate bristol myers squibb 1 p 20-jun-03 z 21-387 pravigard pac aspirin; pravastatin sodium bristol myers squibb 4 s 24-jun-03 1169 21500 emtriva emtricitabine gilead 1 s 02-jul-03 21299 paroxetine mesylate paroxetine mesylate synthon pharms 2 s 03-jul-03 20452 paraplatin carboplatin bristol myers squibb 3 s 14-jul-03 21505 keppra levetiracetam ucb 3 s 15-jul-03 z 21537 ciprodex ciprofloxacin; dexamethasone alcon 3 s 18-jul-03 21535 clobex clobetasol propionate galderma labs lp 3 s 24-jul-03 1179 21372 aloxi palonosetron hydrochloride helsinn hlthcare 1 s 25-jul-03 21546 rebetol ribavirin schering 3 p 29-jul-03 21348 zavesca miglustat actelion pharms 1 sv 31-jul-03 1167 21366 crestor rosuvastatin calcium ipr 1 s 12-aug-03 1166 21400 levitra vardenafil hydrochloride bayer 1 s 19-aug-03 21515 wellbutrin xl bupropion hydrochloride glaxosmithkline 3 s 28-aug-03 21416 rythmol sr propafenone hydrochloride abbott 3 s 04-sep-03 1175 z 21544 seasonale ethinyl estradiol; levonorgesterol barr 3 s 05-sep-03 21591 riomet metformin hydrochloride ranbaxy 3 s 11-sep-03 1175 21572 cubicin daptomycin cubist pharms 1 p 12-sep-03 21575 fosamax alendronate sodium merck 3 s 17-sep-03 1174 21450 zomig zolmitriptan astrazeneca 3 s 30-sep-03 21626 radiogardase prussian blue heyl chemisch- pharmazeutische fabrik gmbh 1 pv 02-oct-03 21371 estrasorb estradiol novavax 3 s 09-oct-03 21489 prohance gadoteridol bracco 3 s 09-oct-03 21487 namenda memantine hydrochloride forest labs 1 s 16-oct-03 21565 elestat epinastine hydrochloride allergan 1 s 16-oct-03 21548 lexiva fosamprenavir calcium glaxosmithkline 2 s 20-oct-03 21346 risperdal consta risperidone johnson and johnson 3 s 29-oct-03 21589 kemstro baclofen schwarz pharma 3 s 30-oct-03 21435 amvaz amlodipine maleate dr reddys labs inc 2 s 31-oct-03 z 21490 ovcon 35 ethinyl estradiol; norethindrone warner chilcott 3 s 14-nov-03 z 21507 prevacid; naprapac lansoprozole; naproxen tap pharm 4 s 14-nov-03 z 21258 climara pro estradiol; levonorgestrel berlex labs 4 s 21-nov-03 1172 21368 cialis tadalafil lilly icos 1 s 21-nov-03 1178 21320 plenaxis abarelix praecis 1 p 25-nov-03 1185 21385 ertaczo sertaconazole nitrate mylan pharms 1 s 10-dec-03 21388 sterile talc powder sterile talc powder bryan corp 3 pv 15-dec-03 z 21451 oraqix lidocaine; prilocaine dentsply pharms 4 s 19-dec-03 1135 21630 vfend voriconazole pfizer inc 3 s 19-dec-03 1178 z 21520 symbyax olanzapine; fluoxetine hydrochloride eli lilly 4 p 24-dec-03 nda approvals for calendar year 2002 ml nda number drug name generic name applicant sponsor ct tc approval date z 21-175 atnaa atropine; pralidoxime chloride us army 3 p 17-jan-02 z 21-112 tri-luma fluocinolone acetonide; hydroquinone; tretinoin hill dermaceuticals 4 s 18-jan-02 21-232 orfadin nitisinone swedish orphan 1 pv 18-jan-02 21-343 eligard leuprolide acetate atrix 3 s 23-jan-02 21-360 sustiva efavirenz bristol myers squibb 3 s 01-feb-02 21-342 levo-t levothyroxine sodium mova 5 s 01-mar-02 21-113 pamidronate disodium pamidronate disodium bedford 5 s 04-mar-02 21-299 asimia paroxetine mesylate synthon pharms 2 s 11-mar-02 21-260 avinza morphine sulfate elan pharm 3 s 20-mar-02 20-855 mesnex mesna bristol myers squibb 3 s 21-mar-02 21-136 secreflo secretin chirhoclin 3 sv 04-apr-02 21-209 secreflo secretin chirhoclin 3 * pv 04-apr-02 21-310 alora estradiol watson labs 3 s 05-apr-02 z 21-373 children's advil cold ibuprofen; pseudoephedrine hcl wyeth consumer healthcare 3 s 18-apr-02 1136 21-286 benicar olmesartan medoxomil sankyo 1 s 25-apr-02 1135 21-344 faslodex fulvestrant astrazeneca 1 s 25-apr-02 21-289 bravelle urofollitropin ferring 3 s 06-may-02 1139 21-272 remodulin treprostinil sodium united therapeutics 1 pv 21-may-02 1135 21-266 vfend voriconazole pfizer 1 s 24-may-02 1135 21-267 vfend voriconazole pfizer 3 s 24-may-02 50784 zithromax azithromycin dihydrate pfizer 3 s 24-may-02 z 21-374 advil cold sinus ibuprofen; pseudoephedrine hcl wyeth consumer healthcare 3 s 30-may-02 z 21-191 imagent kit for the preparation of perflexane lipid microspheres dimyristoylphosphatidylcholine; perflexane alliance pharm 1 s 31-may-02 21-292 novothyrox levothyroxine sodium genpharm 5 s 31-may-02 21-284 ritalin la methylphenidate hcl novartis pharm 3 s 05-jun-02 0958 21-212 caverject alprostadil pharmacia & upjohn 3 s 11-jun-02 1106 20919 geodon ziprasidone mesylate pfizer 3 s 21-jun-02 21-312 clarinex reditabs desloratadine schering 3 s 26-jun-02 1151 21-316 altocor lovastatin aura labs 3 s 26-jun-02 21-282 mucinex guaifenesin adams labs 3 s 12-jul-02 1145 21-196 xyrem sodium oxybate orphan medical 1 pv 17-jul-02 1139 21-200 zelnorm tegaserod maleate novartis pharms 1 p 24-jul-02 * 1132 21-379 eligard leuprolide acetate atrix 3 s 24-jul-02 21-402 synthroid levothyroxine sodium abbott labs 5 s 24-jul-02 21-409 singulair montelukast sodium merck research 3 s 26-jul-02 1148 21-492 eloxatin oxaliplatin sanofi-synthelabo 1 p 09-aug-02 1140 21-323 lexapro escitalopram oxalate forest labs 3 s 14-aug-02 21-241 ortho tri cyclen ethinyl estradiol; norgestimate johnson & johnson 3 s 22-aug-02 z 50741 duac clindamycin phosphate; benzoylperoxide stiefel labs 4 s 26-aug-02 1004 21-447 zanaflex tizanidine hcl elan pharms 3 s 29-aug-02 21-428 prevacid lansoprazole tap 3 s 30-aug-02 21-333 desmopressin acetate desmopressin acetate ferring pharms 5 s 16-sep-02 21-425 ultravist iopromide berlex labs 3 s 20-sep-02 1145 21-449 hepsera adefovir dipivoxil gilead sciences 1 p 20-sep-02 1148 z 50785 augmentin xr amoxicllin; clavulanate potassium glaxosmithkline 3 s 25-sep-02 1156 21-437 inspra eplerenone gd searle 1 s 27-sep-02 21555 chloraprep chlorhexidine gluconate beckloff 3 s 07-oct-02 1150 20732 subutex buprenorphine hcl reckitt benckiser 3 sv 08-oct-02 1150 z 20733 suboxone buprenorphine hcl; naloxone hcl dihydrate reckitt benckiser 4 pv 08-oct-02 1146 z 21410 avandamet metformin hcl; rosiglitazone maleate glaxosmithkline 4 s 10-oct-02 20776 daypro alta oxaprozin potassium pharmacia 2 s 17-oct-02 21408 mentax-tc butenafine hcl bertek 3 s 17-oct-02 21472 ibuprofen ibuprofen banner pharmacaps 3 s 18-oct-02 1146 z 21460 metaglip glipizide; metformin hcl bristol myers squibb 4 s 21-oct-02 21116 thyro-tabs levothyroxine sodium lloyd 5 s 24-oct-02 1151 21445 zetia ezetimibe msp singapore 1 s 25-oct-02 21454 testim testosterone auxilium a2 3 s 31-oct-02 21330 commit nicotine polacrilex glaxosmithkline cons 3 s 31-oct-02 50763 mytozytrex mitomycin supergen 3 s 14-nov-02 1150 21436 abilify aripiprazole otsuka 1 s 15-nov-02 1154 21498 alinia nitazoxanide romark 1 pv 22-nov-02 1149 21318 forteo teriparatide lilly 3 s 26-nov-02 1149 1189 strattera atomoxetine hcl lilly 1 s 26-nov-02 1140 21365 lexapro escitalopram oxalate forest labs 3 s 27-nov-02 1151 21511 copegus ribavirin roche 3 p 03-dec-02 50788 mupirocin mupirocin clay park 3 s 04-dec-02 1147 21375 alavert loratadine wyeth consumer healthcare 3 * s 12-dec-02 1116-17 21473 cipro xr ciprofloxacin bayer 3 s 13-dec-02 21314 idkit: hp 13 c-urea and citrica citric acid ; oridion 3 s 17-dec-02 21419 methylin methylphenidate hcl mallinckrodt 3 s 19-dec-02 z 21441 advil allergy sinus chlorpheniramine maleate; ibuprofen; pseudoephedrine hcl wyeth consumer healthcare 4 s 19-dec-02 21484 bravelle urofollitropin ferring pharms 3 s 19-dec-02 20782 depakote er divalproex sodium abbott labs 3 s 20-dec-02 21321 extraneal icodextrin baxter healthcare 1 sv 20-dec-02 1157 21023 restasis cyclosporine allergan 3 p 23-dec-02 1165 21470 finacea azelaic acid berlex 3 s 24-dec-02 1155 21016 relpax eletriptan hydrobromide pfizer 1 s 26-dec-02 21478 zovirax acyclovir glaxosmithkline 3 s 30-dec-02 21453 zerit xr stavudine bristol myers squibb 3 s 31-dec-02 nda approvals for calendar year 2001 ml nda number drug name generic name applicant sponsor ct tc approval date 21-252 canasa mesalamine axcan scandipharm 5 p 05-jan-01 0990 21-208 remeron soltab mirtazapine organon 3 s 12-jan-01 1108 21-227 cancidas caspofungin acetate merck research labs 1 p 26-jan-01 z 21-261 monistat 3 combination pack miconazole nitrate personal products 4 s 02-feb-01 50-783 periostat doxycycline hyclate collagenex pharms 3 s 02-feb-01 1106 20-825 geodon ziprasidone hcl pfizer 1 s 05-feb-01 21-231 zomig zmt zolmitriptan astra zeneca pharms 3 s 13-feb-01 1104 20-831 foradil formoterol fumarate novartis 1 s 16-feb-01 50-781 arestin minocycline hcl orapharma 3 s 16-feb-01 1103 21-153 nexium esomeprazole magnesium astra zeneca 2 s 20-feb-01 z 21-265 infuvite pediatric multiple vitamins sabex 5 s 21-feb-01 50-780 cefuroxime for injection and dextrose for injection in duplex container cefuroxime sodium b aun 5 s 21-feb-01 1101 21-235 prozac weekly fluoxetine hcl eli lilly 3 s 26-feb-01 1107 21-169 reminyl galantamine hydrobromide janssen research 1 s 28-feb-01 z 21-082 tavist allergy sinus headache acetaminophen clemastine fumarate pseudoephedrine hcl novartis 4 s 01-mar-01 21-257 travatan travoprost alcon 1 p 16-mar-01 21-262 alphagan p brimonidine tartrate allergan 3 s 16-mar-01 21-275 lumigan bimatoprost allergan 1 p 16-mar-01 z 20-950 duoneb albuterol sulfate ipratropium bromide dey labs 4 s 21-mar-01 1129 20-988 protonix pantoprazole sodium wyeth-ayerst 3 s 22-mar-01 21-304 valcyte valganciclovir hcl roche 2 p 29-mar-01 21-160 phoslo calcium acetate braintree lab 3 s 02-apr-01 1114 21-259 metadate cd methylphenidate hcl celltech pharms 3 s 03-apr-01 20-983 ventolinhfa albuterol sulfate glaxosmithkline 3 s 19-apr-01 20-949 accuneb albuterol sulfate dey 5 s 30-apr-01 21-281 prevacid lansoprazole tap pharm 3 s 03-may-01 1124 21-001 axert almotriptan malate pharmacia & upjohn 1 s 07-may-01 1106 21-335 gleevec imatinib mesylate novartis 1 pv 10-may-01 1133 z 21-098 yasmin drospirenone ethinyl estradiol berlex labs 1, 4 s 11-may-01 21-285 trileptal oxcarbazepine novartis 3 s 25-may-01 21-301 levoxyl levothyroxine sodium jones pharma 5 s 25-may-01 z 21-074 avagard alcohol chlorhexidine gluconate 3m 3 s 07-jun-01 1107 21-224 reminyl galantamine hydrobromide janssen research 3 s 22-jun-01 z 50-755 augmentin es-600 amoxicillin clavulanate potassium glaxosmithkline 3 s 22-jun-01 z 21-105 phenazopyridine hcl sulfamethoxazole trimethoprim phenazopyridine hcl sulfamethoxazole trimethoprim able labs 4 s 26-jun-01 21-238 kytril granisetron hcl roche 3 s 27-jun-01 1132 21-288 trelstar triptorelin pamoate pharmacia and 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Mr. ANNUNZIO. Our' first witness this morning is the Honorable Jeffrey &I.Bucher, Governor of the Federal Reserve Board. After Governor Bucher we will hear from James Smith, senior vice president, Security Pacific National Bank of Los Angeles, Calif. This afternoon at : p.m. wc 11-ill hear fronl Katllleeu O'Reilly, legislative ! director ant1 stati attornev for tht. Consllmer Fe lerntioi1 of America. Governor Bucher, I welcome you again to the meeting of the subcommittee and you can proceecl in your own fashion and acebutolol
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