PERSON TRACKING IN SMART ROOMS USING DYNAMIC PROGRAMMING AND ADAPTIVE SUBSPACE LEARNING Zhenqiu Zhang, Beckman Institute, United States; Gerasimos Potamianos, Stephen Chu, IBM T. J. Watson Research Center, United States; Jilin Tu, Beckman Institute, United States; Thomas S. Huang, University of Illinois at Urbana-Champaign, United States.
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358. Renoult E, et al. Effect of topical rifamycin SV treatment on cyclosporine A blood levels in a renal transplant recipient. Eur J Clin Pharmacol 1991; 40 4 ; : 433-434. 359. Moravek J, et al. Pharmacokinetics of roxithromycin in kidney grafted patients under cyclosporine A or azathioprine immunosuppression and in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 1990; 28 6 ; : 262-267. 360. Billaud E, et al. Roxithromycin and cyclosporine: searching for an interaction. Therapie 1990; 45 1 ; : abstr 41. 361. Billaud EM, et al. Interaction between roxithromycin and cyclosporine in heart transplant patients. Clin Pharmacokinet 1990; 19 6 ; : 499-502. 362. Markham A, Fauld D. Roxithromycin: an update of its antimicrobial activity, pharmacokinetic properties and therapeutic use. Drugs 1994; 48 2 ; : 297-326. 363. Barbir M, et al. Low-dose simvastatin for the treatment of hypercholesterolaemia in recipients of cardiac transplantation. Int J Cardiol 1991; 33: 241-246. Munoz MA, et al. Simvastatin SIM ; therapy of hypercholesterolemia associated with chronic rejection CR ; after renal transplantation RT ; , a prospective study. Kidney Int 1993; 44 6 ; : 1497. 365. Hernandez BE, et al. Low-dose simvastatin is safe in hyperlipidaemic renal transplant patient. Nephrol Dial Transplant 1993; 8: 637-641. Campana C, et al. Efficacy and pharmacokinetics of simvastatin in heart transplant recipients. Ann Pharmacother 1995; 29: 235-238. Guillemain R, et al. The effects of spiramycin on plasma cyclosporine A concentrations in heart transplant patients. Eur J Clin Pharmacol 1989; 36: 97-98. Spes CH, et al. Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration. Clin Invest 1992; 70: 752-754. Fox BC, et al. A prospective, randomized, double-blind study of trimethoprim sulfamethoxazole for prophylaxis of infection in renal transplantation: clinical efficacy, absorption of trimethoprim-sulfamethoxazole, effects on the microflora, and the cost-benefit of prophylaxis. J Med 1990; 89 3 ; : 225-274. 370. Kimmel PL, et al. In vitro and in vivo interaction of sulfamethoxazole SMX ; with cyclosporin A CSA ; measurement by high pressure liquid chromatography HPLC ; . Kidney Int 1985; 27: 343. Brouwers JRBJ, et al. Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs. Clin Pharmacokinet 1994; 27 6 ; : 462-485. 372. Seifeldin R. Drug interactions in transplantation. Clin Ther 1995; 17 6 ; : 1043-1061. 373. Armitage JM, et al. A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. Transplant Proc 1991; 23 1 ; : 1149-1152. 374. Fung JJ, et al. Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications. Transplant Proc 1990; 22: 6-12. Toffoli G, et al. Cyclosporine A as a multidrug-resistant modulator in patients with renal cell carcinoma treated with teniposide. Br J Cancer 1997; 75 5 ; : 715-721. 376. Jurima-Romet M, et al. Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals. Drug Metab Dispos 1994; 22 6 ; : 849-857. 377. Potier M, et al. Evidence for a protective effect of theophylline and caffeine on cyclosporine-induced contractions in two in vivo glomerular models. Transplant Proc 1994; 27 4 ; : 2492-2494. 378. Ito MK, et al. Ticlopidine: a new platelet aggregation inhibitor. Clin Pharm 1992; 11: 603-617. Birmele B, et al. Interaction of cyclosporine and ticlopidine. Nephrol Dial Transplant 1991; 6: 150-151. DeLorgeril M, et al. Evaluation of ticlopidine, a novel inhibitor of platelet aggregation, in heart transplant recipients. Transplantation 1993; 55 5 ; : 1195-1196. 381. Desager JP. Clinical pharmacokinetics of ticlopidine. Clin Pharmacokinet 1994; 26 5 ; : 347-355. 382. Cyclosporine drug interactions. Drug Info Bull 1987 Jan; 21 1 ; . 383. Tesi RJ, et al. Calcium antagonists potentiate cyclosporine effects on human lymphocytes. Surg Forum 1985; 36: 339-340. Lewis LD, et al. The macrolide triacetyloleandomycin TAO ; enhances the immunosuppressive effect of cyclosporine A CsA ; on stimulated human lymphocytes in vitro. Clin Res 1994; 42 2 ; : 250A. 385. Gutzler F, et al. Ursodeoxycholic acid enhances the absorption of cyclosporine in a heart transplant patient with short bowel syndrome. Transplant Proc 1992; 24 6 ; : 2620-2621. 386. Sharobeem R, et al. Cyclosporine A and ursodeoxycholic acid interaction. Clin Transplant 1993; 7: 223-226. Gutzler F, et al. Improved bioavailability of cyclosporine by coadministration of urodeoxycholic acid. Gastroenterology 1992; 102 4 part 2 ; : A816. 388. Al-Quaiz MN, et al. Variable effect of ursodeoxycholic acid on cyclosporine absorption after orthotopic liver transplantation. Transplant Int 1994; 7 3 ; : 190-194. 389. Versluis DJ, et al. Cyclosporine A impairs the humoral immune response after influenza vaccination in renal transplant recipients. Transplant Proc 1986; 18 5 ; : 1348-1349. 390. Beyer, WEP, et al. Double failure of influenza vaccination in a heart transplant patient. Transplantation 1987; 43 2 ; : 319. 391. Advisory Committee on Immunization Practices. General recommendations on immunization. MMWR 1989; 38 13 ; : 205-228. 392. Sturrock NDC, et al. The mechanisms involved in cyclosporine induced hypertension and nephrotoxicity in man. Clin Sci 1993; 85 1 ; : 41P. 393. Sharpe MD, Gelb AW. Cyclosporine potentiates vecuronium blockade and prolongs recovery time in humans. Can J Anaesth 1992; 39 5 part 2 ; : A126. 394. Ganjoo P, Tewari P. Oral cyclosporine-vecuronium interaction. Can J Anaesth 1994; 41 10 ; : 1017. 395. Dawidson I, Rooth P. Improvement of cadaver renal transplantation outcomes with verapamil: a review. J Med 1991; 90 5A ; : 37S-41S. 396. Pearigen PD, Benowitz NL. Poisoning due to calcium antagonists. Experience with verapamil, diltiazem and nifedipine. Drug Saf 1991; 6 ; : 408-430. 397. Perkal MF, et al. Severe gingival overgrowth associated with cyclosporine and verapamil therapy. Clin Transplant 1992; 6: 399-402. Castelao AM, et al. Calcium antagonists verapamil ; versus ACE-I enalapril ; in tthe treatment of hypertension of kidney transplanted patients under cyclosporine A and prednisone immunosuppression. A randomized study. Kidney Int 1993; 44 6 ; : 1439-1440. 399. Pirsch JD, et al. A controlled, double-blind, randomized trial of verapmil and cyclosporine in cadaver renal transplant patients. J Kidney Dis 1993; 21 2 ; : 189-195. 400. Erken U, et al. Beneficial effects of verapamil in renal transplantation. Transplant Proc 1993; 25: 2187. Dawidson I, et al. Verapamil VP ; improves the outcome after renal transplantation CRT ; . Transplant Int 1992; 5 suppl 1 ; : S60-S62. 402. Regazzi MB, et al. Clinical pharmacokinetics of verapamil in heart transplant patients under cyclosporine based immunosuppression. Ther Drug Monit 1995; 17 4 ; : 396. 403. Shah IA, et al. The effects of retinoids and terbinafine on the human hepatic microsomal metabolism of cyclosporine. Br J Dermatol 1993; 129: 395-398. Mathieu C, et al. Potential role of 1, 25 OH ; vitamin D3 as a dose-reducing agent for cyclosporine and FK506. Transplant Proc 1994; 26 6 ; : 3130. 405. Sokol RJ, et al. Use of water-soluble vitamin E to improve cyclosporine CS ; absorption in pediatric liver transplantation patients. Hepatology 1990; 12 4 part 2 ; : 865. 406. Holt DW, Johnston A. Cyclosporine and vitamin E. Lancet 1991; 338: 697. Anonymous. Cyclosporine costs reduced with vitamin E co-administration. Pharm J 1991; 247: 210. Chang T, et al. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996; 59 3 ; : 297-303. 409. Pan SH, et al. Enhanced oral cyclosporine absorption with water soluble vitamin E early after liver transplantion. Pharmacotherapy 1996; 16 1 ; : 59-65. 410. Chang T, et al. The effects of water-soluble vitamin E TPGS ; on oral cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1995; 57 2 ; : 163. 411. Sokol, R.J. et al. Improvement of cyclosporine absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991; 338: 212-215. Pan SH, et al. Improved oral cyclosporine absorption with liquid-E in the early post-transplant period. Pharmacotherapy 1992; 12 3 ; : 256.
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Pharmacokinetic Endpoints: . Salmeterol, comparisons of Cmax and tmax. Parameter Comparison Ratio 90% confidence interval p-value Cmax A B Day 8 [Tmd + Ssd Ssd] * 1.0597 0.7437, 1.5100 Css, max ; A B Day 18 [Tmd + Smd Smd] 1.2153 0.8529, 1.7316 C B Day 8 [Smd Ssd] 1.6137 1.1211, 2.3229 B B Day 18 & Day 8 [Smd Ssd] 1.2875 0.9036, 1.8345 C B Day 18 [Smd Ssd] 1.3982 0.9609, 2.0346 tmax A-B Day 8 [Tmd + Ssd - Ssd] 0 -2, 1.0 0.7813 tss, max ; A-B Day 18 [Tmd + Smd - Smd] 0.5 -0.5, 4.0 0.3242 C-B Day 8 [Smd - Ssd] 0.5 -1.5, 2.5 0.5781 B-B Day 18 & Day 8 [Smd - Ssd] -0.5 -2.5, 0 0.2500 C-B Day 18 [Smd - Ssd] 0.5 -1.0, 2.0 0.6406 Ratio is a comparison of the least squares means; median difference for tmax. Cmax maximum plasma concentration; Css, max Cmax at steady state; tss, max tmax at steady state. * T terfenadine, S salmeterol, E erythromycin, sd single dose, md multiple dose Terfenadine, comparisons of area under the plasma concentration-time curve AUC ; , Cmax and tmax Parameter Comparison * Ratio 90% confidence interval p-value Css, max A Day 18 A Day 7 1.0006 0.7636, AUCt A Day 18 A Day 7 0.7689 0.6083, tss, max A Day 18-A Day 7 -1.5085 -0.00825, 0.2415 0.7938 Ratio is a comparison of the least squares means; median difference for tmax. AUC to time t. * [Terfenadine multiple dose Terfenadine multiple dose + Salmeterol multiple dose] Full characterisation of the effect of steady state levels of salmeterol on the pharmacokinetics of terfenadine at steady state was not possible due to high levels of variability in pharmacokinetic parameters Safety results: Adverse events were collected throughout the study. One subject had their medication temporarily suspended due to an episode of nausea and vomiting. Treatment was suspended for 3 days after which treatment was reintroduced. Adverse Events: 1 2 3 No. subjects with AEs n % ; 4 27 ; Most Frequent AEs n % ; Headache 1 7 ; 2 Tremors 0 2 13 ; Equilibrium disorders 0 1 7 ; Viral ear, nose & throat 0 2 13 ; infection Upper respiratory 0 0 2 inflammation Nausea & vomiting 1 7 ; 1 Palpitations 0 0 2.
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Tested it out on TTeam Who Age Absolute Reading start at 2.5" ; Vic 59 3.015" Eric 23 2.845" Larry 61 2.975" Apart from absolute measurements, find out profile of people o Are they in the sun a lot? o Dependent on weight? Fat? Size? Check out Unilever's studies o Correlate with age - any other factors? Change TITLE! 1. How "healthy" is your skin today? Not "old". Measurement: 2. Arm flexed vs. extended 3. Take at least 5 readings per person 4. Bribe people with body lotion candy food 5. Plot confidence, deviation 6. Difference over a few days 7. Categorize measurements by info of people 8. Consider a stretch, relax, stretch again maybe different behaviour 9. One button: press button and it springs open 10. Make the measurement area small enough to test on different parts of body 11. Maybe total all readings from different parts? Like fat calipers Compare with linear skin rheometer Do a trade-off matrix : 12. Function, feature, ways to measure 13. give values to each trade 14. include sketch designer thinking or numbers analyst and thalomid.
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Decreases conversion of prothrombin to thrombin, decreases the prothrombin time or decreases the production of Vitamin K. N V D, hemorrhage, leukopenia, thrombocytopenia, GI bleed, rash, alopecia, urticaria, hematuria, heavy menstrual flow, decreased renal flow, asthma, rhinitis, lacrimation. Danaproid: dizziness, fatigue, headache, viral infection, hypotension, neutropenia, injection site reaction. Bleeding disorders, hepatic or renal disease, psychosis, pregnancy, lactation, TB. Use cautiously in allergies, elderly, CHF, diabetes, alcoholism, pregnancy, postpartum, salicylates. Hypersensitivity to low molecular weight heparins, beef, pork products, use caution with sulfite sensitivity. Danaproid: Uncontrolled hypertension, brain surgery, blood dyscrasias, bowel ulcerations. Arixtra: Bacterial endocarditis. Vitamin K-rich foods may decrease effects of oral anticoagulants e.g., leafy green vegetables, broccoli ; . Many drug interactions. Consult additional reference if side effects, interactions differ from those listed. May increase activity of neurotransmitters by inhibiting presynaptic reuptake of norepinephrine serotonin. Other actions include inhibiting histamine activity, causing sedation, anticholinergic, vasodilator effects. Uses: Primarily to treat major depression, depressive phase of bipolar disease, depressive stages of schizophrenia, phobic disorders, attention deficit disorders, management of eating disorders, used off label as an adjunctive therapy for pain. Most commonly related to anticholinergic dry mouth, blurred vision, constipation, urinary retention ; , CNS activity drowsiness, fatigue ; , tardive dyskinesia, neuropathies, dizziness, orthostatic hypotension, jaundice, allergic sensitivity, GI effects, change in libido, cardiac changes, weight changes, photosensitivity, bone marrow depression, hallucinations, agitation, endocrine changes male female hormone-like effects ; , cough. Prostatic hypertrophy, urinary retention, glaucoma, increased intraocular pressure, hyperthyroidism, seizure disorders, cardiovascular disease, psychiatric patients schizophrenic paranoid ; suicide risks, pregnancy, lactation, children, electroconvulsive therapy, tartrazine sulfite sensitivity. MAO inhibitors, hypotensive agents, CNS depressants: alcohol, barbiturates, sedatives, hypnotics, cimetidine, adrenergic anticholinergic agents, cclonidine, disulfiram, phenothiazines, dicumarol, fluoxetine, haloperidol, oral contraceptives. ANTIDEPRESSANT SSRI ; 9 Potent, selective inhibition of neuronal serotonin reuptake, weak effect on neuronal reuptake of norepinephrine, dopamine. Uses: Treatment of depression, obsessive compulsive disorder, eating disorders. Headache, insomnia, somnolence, nervousness, anxiety, dizziness, blurred vision, tremor, drowsiness, fatigue, decreased libido, abnormal ejaculation, nausea, diarrhea, dry mouth, anorexia, constipation, diaphoresis, rash, hyponatremia, activation of mania hypomania, seizures, photosensitivity. Renal impairment, hepatic impairment, history of seizures, suicidal tendencies, diabetes, hypersensitivity. MAO inhibitors, phenobarbital, phenytoin, betablockers, bensodiazepines, lithium, tolbutamide, Ltryptophan, alcohol, tricyclic antidepressants. Paroxetine and sertraline - Drugs highly protein bound may result in increased free concentrations of the other drug e.g., warfarin, digoxin, theophylline ; . Paroxetine - Drugs metabolized by the Cytochrome P450 may require lower doses of either parotextine or the other drug e.g., cimetidine ; . Fluoxetine - Dextromethorphan, cyproheptadine, tryptophan, antidepressants, buspirone, carbamazepine, hydantoins, lithium, nicotine, clozapine haloperidol. Fluvoxamine - nonsedating antihistamines, carbamazepine, clozapine, nicotine, diltiazem, haloperidol, methadone, sumatriptan theophylline. Citalopram - Drugs which inhibit C-P450 & C219 will increase levels antifungals, macrolides ; carbamazepine. MAO inhibitors, astemizole, cisapride, terfenadine use, pregnancy, lactation, children and thiamin.
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24. Isaacs, J. S., Jung, Y. J., Mole, D. R., Lee, S., Torres-Cabala, C., Chung, Y. L., Merino, M., Trepel, J., Zbar, B., Toro, J., Ratcliffe, P. J., Linehan, W. M., and Neckers, L. 2005 ; Cancer Cell 8, 143153 25. Briere, J. J., Favier, J., Benit, P., Ghouzzi, V. E., Lorenzato, A., Rabier, D., Di ` Renzo, M. F., Gimenez-Roqueplo, A. P., and Rustin, P. 2005 ; Hum. Mol. Genet. 14, 32633269 26. Bayley, J. P., van Minderhout, I., Weiss, M. M., Jansen, J. C., Oomen, P. H., Menko, F. H., Pasini, B., Ferrando, B., Wong, N., Alpert, L. C., Williams, R., Blair, E., Devilee, P., and Taschner, P. E. 2006 ; BMC Med. Genet. 7, 1 27. Schiavi, F., Boedeker, C. C., Bausch, B., Peczkowska, M., Gomez, C. F., Strassburg, T., Pawlu, C., Buchta, M., Salzmann, M., Hoffmann, M. M., Berlis, A., Brink, I., Cybulla, M., Muresan, M., Walter, M. A., Forrer, F., Valimaki, M., Kawecki, A., Szutkowski, Z., Schipper, J., Walz, M. K., Pigny, P., Bauters, C., Willet-Brozick, J. E., Baysal, B. E., Januszewicz, A., Eng, C., Opocher, G., and Neumann, H. P. 2005 ; J. Am. Med. Assoc. 294, 20572063 28. Bayley, J. P., Devilee, P., and Taschner, P. E. 2005 ; BMC Med. Genet. 6, 39 29. Milunsky, J. M., Maher, T. A., Michels, V. V., and Milunsky, A. 2001 ; Am. J. Med. Genet. 100, 311314 30. Oyedotun, K. S., and Lemire, B. D. 1997 ; J. Biol. Chem. 272, 3138231388 31. Oyedotun, K. S., and Lemire, B. D. 1999 ; J. Biol. Chem. 274, 23956 23962 Rothstein, R. 1991 ; Methods Enzymol. 194, 281301 33. Bullis, B. L., and Lemire, B. D. 1994 ; J. Biol. Chem. 269, 6543 6549 de Kok, J., Muller, J. L. M., and Slater, E. C. 1975 ; Biochim. Biophys. Acta 387, 441 450 Sarkar, G., and Sommer, S. S. 1990 ; BioTechniques 8, 404 407 Robinson, K. M., von Kieckebusch-Guck, A., and Lemire, B. D. 1991 ; J. Biol. Chem. 266, 2134721350 37. Johnson-Cadwell, L. I., Jekabsons, M. B., Wang, A., Polster, B. M., and Nicholls, D. G. 2007 ; J. Neurochem. 6, 1619 1631 Solans, A., Zambrano, A., Rodriguez, M., and Barrientos, A. 2006 ; Hum. Mol. Genet. 15, 30633081 39. Singer, T. P., Rocca, E., and Kearney, E. B. 1965 ; in Flavins and Flavoproteins Slater, E. C., ed ; , pp. 391 420, Elsevier, Amsterdam 40. Kita, K., Vibat, C. R. T., Meinhardt, S., Guest, J. R., and Gennis, R. B. 1989 ; J. Biol. Chem. 264, 26722677 41. Imlay, J. A., and Fridovich, I. 1991 ; J. Biol. Chem. 266, 6957 6965 Saude, E. J., Slupsky, C. M., and Sykes, B. D. 2006 ; Metabolomics 2, 113123 43. Yankovskaya, V., Horsefield, R., Tornroth, S., Luna-Chavez, C., Miyoshi, H., Leger, C., Byrne, B., Cecchini, G., and Iwata, S. 2003 ; Science 299, 700 704 Yang, X., Yu, L., He, D., and Yu, C. A. 1998 ; J. Biol. Chem. 273, 31916 31923 Tran, Q. M., Rothery, R. A., Maklashina, E., Cecchini, G., and Weiner, J. H. 2006 ; J. Biol. Chem. 281, 32310 32317 Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M., and Rao, Z. 2005 ; Cell 121, 10431057 Oyedotun, K. S., Yau, P. F., and Lemire, B. D. 2004 ; J. Biol. Chem. 279, 94329439 Robinson, K. M., and Lemire, B. D. 1995 ; Methods Enzymol. 260, 34 51 Oyedotun, K. S., and Lemire, B. D. 1999 ; Biochim. Biophys. Acta 1411, 170 179 Yanase, S., Yasuda, K., and Ishii, N. 2002 ; Mech. Ageing Dev. 123, 1579 1587 Betarbet, R., Sherer, T. B., and Greenamyre, J. T. 2002 ; Bioessays 24, 308 318 Sun, J., and Trumpower, B. L. 2003 ; Arch. Biochem. Biophys. 419, 198 206 Bruel, C., Brasseur, R., and Trumpower, B. L. 1996 ; J. Bioenerg. Biomembr. 28, 59 68 Brasseur, G., Tron, G., Dujardin, G., Slonimski, P. P., and Brivet-Chevillotte, P. 1997 ; Eur. J. Biochem. 246, 103111 Bakker, B. M., Overkamp, K. M., van Maris, A. J., Kotter, P., Luttik, M. A., van Dijken, J. P., and Pronk, J. T. 2001 ; FEMS Microbiol. Rev. 25, 1537 Dibrov, E., Fu, S., and Lemire, B. D. 1998 ; J. Biol. Chem. 273, 3204232048 Mashego, M. R., Jansen, M. L., Vinke, J. L., van Gulik, W. M., and Heijnen, J. J. 2005 ; FEMS Yeast Res. 5, 419 430 Silkin, Y., Oyedotun, K. S., and Lemire, B. D. 2007 ; Biochim. Biophys. Acta 2, 143150 Huang, L. S., Borders, T. M., Shen, J. T., Wang, C. J., and Berry, E. A. 2005 ; Acta Crystallogr. D Biol. Crystallogr. 61, 380 387 Horsefield, R., Yankovskaya, V., Sexton, G., Whittingham, W., Shiomi, K., Omura, S., Byrne, B., Cecchini, G., and Iwata, S. 2006 ; J. Biol. Chem. 281, 7309 7316 Fedotcheva, N. I., Sokolov, A. P., and Kondrashova, M. N. 2006 ; Free Radic. Biol. Med. 41, 56 64 Lee, S., Nakamura, E., Yang, H., Wei, W., Linggi, M. S., Sajan, M. P., Farese, R. V., Freeman, R. S., Carter, B. D., Kaelin, W. G., Jr., and Schlisio, S. 2005 ; Cancer Cell 8, 155167 King, A., Selak, M. A., and Gottlieb, E. 2006 ; Oncogene 25, 4675 4682 and thioguanine.
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